Determining the Balance Between Drug Efficacy and Safety by the Network and Biological System Profile of Its Therapeutic Target

• Main Authors: Xiao xu Li (Author), Jiayi Yin (Author), Jing Tang (Author), Yinghong Li (Author), Qingxia Yang (Author), Ziyu Xiao (Author), Runyuan Zhang (Author), Yunxia Wang (Author), Jiajun Hong (Author), Lin Tao (Author), Weiwei Xue (Author), Feng Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One of the most challenging puzzles in drug discovery is the identification and characterization of candidate drug of well-balanced profile between efficacy and safety. So far, extensive efforts have been made to evaluate this balance by estimating the quantitative structure-therapeutic relationship...