Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model

• Main Authors: Claudia Tulotta (Author), Cristina Stefanescu (Author), Elena Beletkaia (Author), Jeroen Bussmann (Author), Katsiaryna Tarbashevich (Author), Thomas Schmidt (Author), B. Ewa Snaar-Jagalska (Author)
• Format: Book
• Published: The Company of Biologists, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triple-negative breast cancer (TNBC) is a highly aggressive and recurrent type of breast carcinoma that is associated with poor patient prognosis. Because of the limited efficacy of current treatments, new therapeutic strategies need to be developed. The CXCR4-CXCL12 chemokine signaling axis guides...