Combination Treatment of Resistant Acute Promyelocytic Leukemia Cells with Arsenic Trioxide and Anti-Apoptotic Gene Inhibitors

• मुख्य लेखकों: Manuela Giansanti (लेखक), Tiziana Ottone (लेखक), Serena Travaglini (लेखक), Maria Teresa Voso (लेखक), Grazia Graziani (लेखक), Isabella Faraoni (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2024-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Background: Arsenic trioxide (ATO) is an anticancer agent for treating acute promyelocytic leukemia (APL). However, 5-10% of patients fail to respond, developing relapsed/refractory disease. The aim of this study was to identify potential new therapeutic approaches for ATO-unresponsive APL by target...