Combination Treatment of Resistant Acute Promyelocytic Leukemia Cells with Arsenic Trioxide and Anti-Apoptotic Gene Inhibitors

• Κύριοι συγγραφείς: Manuela Giansanti (Συγγραφέας), Tiziana Ottone (Συγγραφέας), Serena Travaglini (Συγγραφέας), Maria Teresa Voso (Συγγραφέας), Grazia Graziani (Συγγραφέας), Isabella Faraoni (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2024-11-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Background: Arsenic trioxide (ATO) is an anticancer agent for treating acute promyelocytic leukemia (APL). However, 5-10% of patients fail to respond, developing relapsed/refractory disease. The aim of this study was to identify potential new therapeutic approaches for ATO-unresponsive APL by target...