Electrical Pulse Stimulation Protects C2C12 Myotubes against Hydrogen Peroxide-Induced Cytotoxicity via Nrf2/Antioxidant Pathway

• Main Authors: Sarah Pribil Pardun (Author), Anjali Bhat (Author), Cody P. Anderson (Author), Michael F. Allen (Author), Will Bruening (Author), Joel Jacob (Author), Ved Vasishtha Pendyala (Author), Li Yu (Author), Taylor Bruett (Author), Matthew C. Zimmerman (Author), Song-Young Park (Author), Irving H. Zucker (Author), Lie Gao (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Skeletal muscle contraction evokes numerous biochemical alterations that underpin exercise benefits. This present study aimed to elucidate the mechanism for electrical pulse stimulation (EPS)-induced antioxidant adaptation in C2C12 myotubes. We found that EPS significantly upregulated Nrf2 and a bro...