Disruption of Nrf2 Enhances Upregulation of Nuclear Factor-κB Activity, Proinflammatory Cytokines, and Intercellular Adhesion Molecule-1 in the Brain after Traumatic Brain Injury

• Main Authors: Wei Jin (Author), Handong Wang (Author), Wei Yan (Author), Lizhi Xu (Author), Xiaoliang Wang (Author), Xiaoning Zhao (Author), Xiaohe Yang (Author), Gang Chen (Author), Yan Ji (Author)
• Format: Book
• Published: Hindawi Limited, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammatory response plays an important role in the pathogenesis of secondary brain injury after traumatic brain injury (TBI). Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor that plays a crucial role in cytoprotection against inflammation. The present study investi...