Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-Based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses

Co-delivery of antigens and adjuvants to the same antigen-presenting cells (APCs) can significantly improve the efficacy and safety profiles of vaccines. Here, we report amine-grafted silica nanoparticles (A-SNP) as a tunable vaccine co-delivery platform for TLR7/8 agonists along with the recombinan...

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Main Authors: Walid M. Abdelwahab (Author), Sarah Auclair (Author), Timothy Borgogna (Author), Karthik Siram (Author), Alexander Riffey (Author), Hélène G. Bazin (Author), Howard B. Cottam (Author), Tomoko Hayashi (Author), Jay T. Evans (Author), David J. Burkhart (Author)
Format: Book
Published: MDPI AG, 2024-01-01T00:00:00Z.
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