Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury

• Main Authors: James G. Macfarlane (Author), David A. Dorward (Author), Marie-Hélène R (Author), Jonathan Scott (Author), Christopher D. Lucas (Author), Adriano G. Rossi (Author), A. John Simpson (Author)
• Format: Book
• Published: BMC, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Neutrophils rapidly respond to and clear infection from tissues, but can also induce tissue damage through excessive degranulation, when acute inflammation proceeds unchecked. A number of key neutrophil functions, including adhesion-dependent degranulation, are controlled by src...