Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury

• Váldodahkkit: James G. Macfarlane (Dahkki), David A. Dorward (Dahkki), Marie-Hélène R (Dahkki), Jonathan Scott (Dahkki), Christopher D. Lucas (Dahkki), Adriano G. Rossi (Dahkki), A. John Simpson (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: BMC, 2020-10-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Abstract Background Neutrophils rapidly respond to and clear infection from tissues, but can also induce tissue damage through excessive degranulation, when acute inflammation proceeds unchecked. A number of key neutrophil functions, including adhesion-dependent degranulation, are controlled by src...