Evaluation of the inhibition performance of pyrrole derivatives against CYP450 isoforms

• मुख्य लेखकों: Magdalena Kondeva-Burdina (लेखक), Emilio Mateev (लेखक), Ali Irfan (लेखक), Hristina Kuteva (लेखक), Maya Georgieva (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Pensoft Publishers, 2024-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Cytochrome P450 is a heme-containing superfamily accountable for the oxidation of various pharmacologically active drugs. The aim of this study was to conduct in silico and in vitro activity assessments of recently synthesized pyrrole-based compounds against three major CYP450 isoforms - CYP1A2, CYP...