Capsaicin Is a Negative Allosteric Modulator of the 5-HT3 Receptor

• Автори: Eslam El Nebrisi (Автор), Tatiana Prytkova (Автор), Dietrich Ernst Lorke (Автор), Luke Howarth (Автор), Asma Hassan Alzaabi (Автор), Keun-Hang Susan Yang (Автор), Frank C. Howarth (Автор), Murat Oz (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

In this study, effects of capsaicin, an active ingredient of the capsicum plant, were investigated on human 5-hydroxytryptamine type 3 (5-HT3) receptors. Capsaicin reversibly inhibited serotonin (5-HT)-induced currents recorded by two-electrode voltage clamp method in Xenopus oocytes. The inhibition...