Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle

• Main Authors: Ulrich Stifel (Author), Eva-Maria Wolfschmitt (Author), Josef Vogt (Author), Ulrich Wachter (Author), Sabine Vettorazzi (Author), Daniel Tews (Author), Melanie Hogg (Author), Fabian Zink (Author), Nora Maria Koll (Author), Sandra Winning (Author), Rémi Mounier (Author), Bénédicte Chazaud (Author), Peter Radermacher (Author), Pamela Fischer-Posovszky (Author), Giorgio Caratti (Author), Jan Tuckermann (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Glucocorticoids (GCs) are one of the most widely prescribed anti-inflammatory drugs. By acting through their cognate receptor, the glucocorticoid receptor (GR), GCs downregulate the expression of pro-inflammatory genes and upregulate the expression of anti-inflammatory genes. Metabolic p...