Genetic Ablation of the Mitochondrial Calcium Uniporter (MCU) Does not Impair T Cell-Mediated Immunity In Vivo

• Main Authors: Hao Wu (Author), Benjamin Brand (Author), Miriam Eckstein (Author), Sophia M. Hochrein (Author), Magdalena Shumanska (Author), Jan Dudek (Author), Alexander Nickel (Author), Christoph Maack (Author), Ivan Bogeski (Author), Martin Vaeth (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

T cell activation and differentiation is associated with metabolic reprogramming to cope with the increased bioenergetic demand and to provide metabolic intermediates for the biosynthesis of building blocks. Antigen receptor stimulation not only promotes the metabolic switch of lymphocytes but also...