Mycolactone induces cell death by SETD1B-dependent degradation of glutathione.

• Ngā kaituhi matua: Birgit Förster (Author), Caroline Demangel (Author), Thorsten Thye (Author)
• Hōputu: Pukapuka
• I whakaputaina: Public Library of Science (PLoS), 2020-10-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Mycobacterium ulcerans is a human pathogen that causes a necrotizing skin disease known as Buruli ulcer. Necrosis of infected skin is driven by bacterial production of mycolactone, a diffusible exotoxin targeting the host translocon (Sec61). By blocking Sec61, mycolactone prevents the transport of n...