A Study on Repositioning Nalidixic Acid via Lanthanide Complexation: Synthesis, Characterization, Cytotoxicity and DNA/Protein Binding Studies

• Main Authors: Ana-Madalina Maciuca (Author), Alexandra-Cristina Munteanu (Author), Mirela Mihaila (Author), Mihaela Badea (Author), Rodica Olar (Author), George Mihai Nitulescu (Author), Cristian V. A. Munteanu (Author), Valentina Uivarosi (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

"Drug repositioning" is a modern strategy used to uncover new applications for out-of-date drugs. In this context, nalidixic acid, the first member of the quinolone class with limited use today, has been selected to obtain nine new metal complexes with lanthanide cations (La<sup>3+&l...