Mechanism of Beraprost Effects on Pulmonary Hypertension: Contribution of Cross-Binding to PGE2 Receptor 4 and Modulation of O2 Sensitive Voltage-Gated K+ Channels

• Main Authors: Fenling Fan (Author), Hua Tian (Author), Jie Geng (Author), Jizhao Deng (Author), Ya Liu (Author), Chunyan Chen (Author), Songlin Zhang (Author), Yushun Zhang (Author), Jie Li (Author), Hongyan Tian (Author), Anthony M. Dart (Author), Yuliang Zou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The purpose of this study is to elucidate mechanism(s) by which the orally active PGI2 analog, Beraprost (BPS), ameliorates pulmonary hypertension (PH). Prostaglandins are an important treatment for PH. Mechanisms of their action are not fully elucidated in relation to receptor subtype a...