Protective effect of dexmedetomidine against delayed bone healing caused by morphine via PI3K/Akt mediated Nrf2 antioxidant defense system

• Main Authors: Yani Lou (Author), Linfang Zou (Author), Zhenyu Shen (Author), Jianwei Zheng (Author), Yuanqu Lin (Author), Zhe Zhang (Author), XuanKuai Chen (Author), Jun Pan (Author), Xutong Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundAs a class of analgesics, opioids are frequently used to treat both acute and chronic moderate to severe pain. Patients frequently receive opioid painkillers after orthopedic accidents or surgeries. Evidence suggests that opioid drug users have a 55.1% higher risk of fracture and poor bone...