Integrin alpha-5 silencing leads to myofibroblastic differentiation in IPF-derived human lung fibroblasts

• Main Authors: Gali Epstein Shochet (Author), Elizabetha Brook (Author), Becky Bardenstein-Wald (Author), Hanna Grobe (Author), Evgeny Edelstein (Author), Lilach Israeli-Shani (Author), David Shitrit (Author)
• Format: Book
• Published: SAGE Publishing, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and objective: The term 'fibroblast' covers a heterogeneous cell population in idiopathic pulmonary fibrosis (IPF). The fibroblasts are considered as main effector cells, because they promote disease progression by releasing exaggerated amounts of extracellular matrix proteins a...