Association of NQO2 With UDP-Glucuronosyltransferases Reduces Menadione Toxicity in Neuroblastoma Cells

• Main Authors: Monivan Chhour (Author), Pierre Perio (Author), Regis Gayon (Author), Hélène Ternet-Fontebasso (Author), Gilles Ferry (Author), Françoise Nepveu (Author), Jean A. Boutin (Author), Jan Sudor (Author), Karine Reybier (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The balance between detoxification and toxicity is linked to enzymes of the drug metabolism Phase I (cytochrome P450 or oxidoreductases) and phase II conjugating enzymes (such as the UGTs). After the reduction of quinones, the product of the reaction, the quinols-if not conjugated-re-oxidizes sponta...