LFA-1/ ICAM-1 promotes NK cell cytotoxicity associated with the pathogenesis of ocular toxoplasmosis in murine model.

• Main Authors: Nannan Gao (Author), Chong Wang (Author), Yiran Yu (Author), Linding Xie (Author), Yien Xing (Author), Yuan Zhang (Author), Yanling Wang (Author), Jianjun Wu (Author), Yihong Cai (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ocular toxoplasmosis (OT) is one of the most common causes of posterior uveitis. However, the pathogenic mechanisms of OT have not been well elucidated. Here, we used C57BL/6 (B6) mice to establish OT by peroral infection with 20 cysts of the TgCtWh6 strain, and severe ocular damage was observed by...