Immunomodulatory role of phagocyte-derived chloramines involving lymphocyte glutathione

• Main Authors: Véronique Witko-Sarsat (Author), Anh Thu Nguyen (Author), Béatrice Descamps-Latscha (Author)
• Format: Book
• Published: Hindawi Limited, 1993-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study shows that human lymphocytes markedly decrease chloramines (long-lived oxidants) generated by polymorphonuclear neutrophils (PMN) after stimulation by phorbol-myristate-acetate or opsonized zymosan. In a cell-free model, reduced glutathione (GSH) scavenged chloramines, giving rise to oxid...