Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke

• Main Authors: Zexuan Hong (Author), Jun Cao (Author), Dandan Liu (Author), Maozhu Liu (Author), Mengyuan Chen (Author), Fanning Zeng (Author), Zaisheng Qin (Author), Jigang Wang (Author), Tao Tao (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Stroke is the second leading cause of death worldwide, and oxidative stress plays a crucial role. Celastrol exhibits strong antioxidant properties in several diseases; however, whether it can affect oxidation in cerebral ischemic-reperfusion injury (CIRI) remains unclear. This study aimed to determi...