Integration of multiple lineage measurements from the same cell reconstructs parallel tumor evolution

• Main Authors: Lennart Kester (Author), Buys de Barbanson (Author), Anna Lyubimova (Author), Li-Ting Chen (Author), Valérie van der Schrier (Author), Anna Alemany (Author), Dylan Mooijman (Author), Josi Peterson-Maduro (Author), Jarno Drost (Author), Jeroen de Ridder (Author), Alexander van Oudenaarden (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Organoid evolution models complemented with integrated single-cell sequencing technology provide a powerful platform to characterize intra-tumor heterogeneity (ITH) and tumor evolution. Here, we conduct a parallel evolution experiment to mimic the tumor evolution process by evolving a colon...