Integration of multiple lineage measurements from the same cell reconstructs parallel tumor evolution

• Главные авторы: Lennart Kester (Автор), Buys de Barbanson (Автор), Anna Lyubimova (Автор), Li-Ting Chen (Автор), Valérie van der Schrier (Автор), Anna Alemany (Автор), Dylan Mooijman (Автор), Josi Peterson-Maduro (Автор), Jarno Drost (Автор), Jeroen de Ridder (Автор), Alexander van Oudenaarden (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2022-02-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Summary: Organoid evolution models complemented with integrated single-cell sequencing technology provide a powerful platform to characterize intra-tumor heterogeneity (ITH) and tumor evolution. Here, we conduct a parallel evolution experiment to mimic the tumor evolution process by evolving a colon...