Alternative Excipients for Protein Stabilization in Protein Therapeutics: Overcoming the Limitations of Polysorbates

• Main Authors: Angel J. Castañeda Ruiz (Author), Maryam A. Shetab Boushehri (Author), Tamara Phan (Author), Stefan Carle (Author), Patrick Garidel (Author), Julia Buske (Author), Alf Lamprecht (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been the most widely used excipients for the stabilization of protein therapeutics for years. In recent decades, however, there have been numerous reports about visible or sub-visible particles in PS-containin...