Intracellular Signaling in Key Pathways Is Induced by Treatment with Ultrasound and Microbubbles in a Leukemia Cell Line, but Not in Healthy Peripheral Blood Mononuclear Cells

• Main Authors: Ragnhild Haugse (Author), Anika Langer (Author), Stein-Erik Gullaksen (Author), Silje Maria Sundøy (Author), Bjørn Tore Gjertsen (Author), Spiros Kotopoulis (Author), Emmet McCormack (Author)
• Format: Book
• Published: MDPI AG, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment with ultrasound and microbubbles (sonoporation) to enhance therapeutic efficacy in cancer therapy is rapidly expanding, but there is still very little consensus as to why it works. Despite the original assumption that pore formation in the cell membrane is responsible for increased uptake...