Protective Effect of Zinc Against Ischemic Neuronal Injury in a Middle Cerebral Artery Occlusion Model

• Main Authors: Youji Kitamura (Author), Yasuhiko Iida (Author), Jun Abe (Author), Masashi Ueda (Author), Masaki Mifune (Author), Fumiyo Kasuya (Author), Masayuki Ohta (Author), Kazuo Igarashi (Author), Yutaka Saito (Author), Hideo Saji (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: In this study, we investigated the effect of vesicular zinc on ischemic neuronal injury. In cultured neurons, addition of a low concentration (under 100 µM) of zinc inhibited both glutamate-induced calcium influx and neuronal death. In contrast, a higher concentration (over 150 µM) of zin...