Lipidomic Analyses Uncover Apoptotic and Inhibitory Effects of Pyrvinium Pamoate on Cholangiocarcinoma Cells via Mitochondrial Membrane Potential Dysfunction

• Main Authors: Yingpinyapat Kittirat (Author), Jutarop Phetcharaburanin (Author), Bundit Promraksa (Author), Thanaporn Kulthawatsiri (Author), Arporn Wangwiwatsin (Author), Poramate Klanrit (Author), Sakkarn Sangkhamanon (Author), Apiwat Jarearnrat (Author), Suyanee Thongchot (Author), Panupong Mahalapbutr (Author), Watcharin Loilome (Author), Hideyuki Saya (Author), Nisana Namwat (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pyrvinium pamoate (PP), an FDA-approved anthelmintic drug, has been validated as a highly potent anti-cancer agent and patented recently as a potential chemotherapeutic drug for various cancers. The aims of this study were, therefore, to investigate the ability of PP in anti-proliferative activity a...