Conditions Conducive to the Glutathionylation of Complex I Subunit NDUFS1 Augment ROS Production following the Oxidation of Ubiquinone Linked Substrates, Glycerol-3-Phosphate and Proline

• Main Authors: Kevin Wang (Author), Jonathan Hirschenson (Author), Amanda Moore (Author), Ryan J. Mailloux (Author)
• Formato: Libro
• Publicado: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Mitochondrial complex I can produce large quantities of reactive oxygen species (ROS) by reverse electron transfer (RET) from the ubiquinone (UQ) pool. Glutathionylation of complex I does induce increased mitochondrial superoxide/hydrogen peroxide (O₂^●−/...