Design and synthesis of doublecortin-like kinase 1 inhibitors and their bioactivity evaluation

• Ngā kaituhi matua: Pengming Pan (Author), Dengbo Ji (Author), Zhongjun Li (Author), Xiangbao Meng (Author)
• Hōputu: Pukapuka
• I whakaputaina: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

AbstractDoublecortin-like kinase 1 (DCLK) is a microtubule-associated serine/threonine kinase that is upregulated in a wide range of cancers and is believed to be related to tumour growth and development. Upregulated DCLK1 has been used to identify patients at high risk of cancer progression and tum...