Evidence That a TRPA1-Mediated Murine Model of Temporomandibular Joint Pain Involves NLRP3 Inflammasome Activation

• Main Authors: Xenia Kodji (Author), Zizheng Kee (Author), Robyn McKenna (Author), Joao de Sousa Valente (Author), Harriet Ravenscroft (Author), Hayley McMillan (Author), John Gamble (Author), Yvonne Dombrowski (Author), Paul Moynagh (Author), David Brough (Author), Fionnuala T. Lundy (Author), Susan D. Brain (Author), Ikhlas A. El Karim (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study investigates the role of transient receptor potential ankyrin 1 (TRPA1) in murine temporomandibular joint (TMJ) inflammatory hyperalgesia and the influence of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome. Two distinct murine models of TMJ pain and inflammation (zymosan an...