Sox9-Increased miR-322-5p Facilitates BMP2-Induced Chondrogenic Differentiation by Targeting Smad7 in Mesenchymal Stem Cells

• Main Authors: Yongsheng Zeng (Author), Chengcheng Du (Author), Pengcheng Xiao (Author), Yiting Lei (Author), Piao Zhao (Author), Zhenglin Zhu (Author), Shengqiang Gao (Author), Bowen Chen (Author), Shengwen Cheng (Author), Wei Huang (Author), Chen Zhao (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone morphogenetic protein 2 (BMP2) induces effective chondrogenesis of mesenchymal stem cells (MSCs) by promoting Sox9 expression. However, BMP2 also induces chondrocyte hypertrophy and endochondral ossification by upregulating Smad7 expression, which leads to the disruption of chondrogenesis. In a...