Activation of Cytosolic Phospholipase A2α by Epidermal Growth Factor (EGF) and Phorbol Ester in HeLa Cells: Different Effects of Inhibitors for EGF Receptor, Protein Kinase C, Src, and C-Raf

• Main Authors: Yasuo Matsuzawa (Author), Yoshiaki Kiuchi (Author), Kaori Toyomura (Author), Ikiru Matsumoto (Author), Hiroyuki Nakamura (Author), Hiromichi Fujino (Author), Toshihiko Murayama (Author), Tatsuo Kawashima (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In several types of cancer cells, prostaglandins produced via the over-expression of epidermal growth factor receptor (EGFR) and cyclooxygenases regulate cell growth. We investigated the signaling mechanisms for the release of arachidonic acid (AA, a precursor for prostaglandins) in human cervical c...