Utilizing induced neural stem cell‐based delivery of a cytokine cocktail to enhance chimeric antigen receptor‐modified T‐cell therapy for brain cancer

• Main Authors: Alex S. Woodell (Author), Elisa Landoni (Author), Alain Valdivia (Author), Andrew Buckley (Author), Edikan A. Ogunnaike (Author), Gianpietro Dotti (Author), Shawn D. Hingtgen (Author)
• Format: Book
• Published: Wiley, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Chimeric antigen receptor (CAR)‐modified T‐cell therapy has shown enormous clinical promise against blood cancers, yet efficacy against solid tumors remains a challenge. Here, we investigated the potential of a new combination cell therapy, where tumor‐homing induced neural stem cells (iNSC...