Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-Cλ interface

• Main Authors: John D. Bagert (Author), Vaheh Oganesyan (Author), Chi-I Chiang (Author), Mike Iannotti (Author), Jia Lin (Author), Chunning Yang (Author), Sterling Payne (Author), Will McMahon (Author), Samuel Edwards (Author), Andrew Dippel (Author), Mark Hutchinson (Author), Fengying Huang (Author), Vineela Aleti (Author), Chendi Niu (Author), Chen Qian (Author), Jessica Denham (Author), Sofia Ferreira (Author), Pallab Pradhan (Author), Mark Penney (Author), Chunlei Wang (Author), Wenhai Liu (Author), Even Walseng (Author), Yariv Mazor (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTBispecific antibodies represent an increasingly large fraction of biologics in therapeutic development due to their expanded scope in functional capabilities. Asymmetric monovalent bispecific IgGs (bsIgGs) have the additional advantage of maintaining a native antibody-like structure, which c...