Characterization of Pathway-Specific Regulator NigR for High Yield Production of Nigericin in <i>Streptomyces malaysiensis</i> F913

• Main Authors: Junhong Wei (Author), Mengting Ma (Author), Senwen Guo (Author), Yaobo Xu (Author), Jie Xie (Author), Guoqing Pan (Author), Zeyang Zhou (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nigericin is a polyether antibiotic with potent antibacterial, antifungal, antimalarial and anticancer activity. NigR, the only regulator in the nigericin biosynthetic gene cluster in <i>Streptomyces malaysiensis</i> F913, was identified as a SARP family regulator. Disruption of <i>...