Effect of a SGLT2 inhibitor on the systemic and intrarenal renin-angiotensin system in subtotally nephrectomized rats

• Main Authors: Lei Li (Author), Yoshio Konishi (Author), Takashi Morikawa (Author), Yifan Zhang (Author), Chizuko Kitabayashi (Author), Hideki Kobara (Author), Tsutomu Masaki (Author), Daisuke Nakano (Author), Hirofumi Hitomi (Author), Hiroyuki Kobori (Author), Akira Nishiyama (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We aimed to examine the effects of a sodium glucose co-transporter 2 (SGLT2) inhibitor on systemic and intrarenal renin-angiotensin system (RAS) in subtotally nephrectomized non-diabetic rats, a model of chronic kidney disease (CKD). Oral administration of the selective SGLT2 inhibitor, TA-1887 (10 ...