Lactoylglutathione promotes inflammatory signaling in macrophages through histone lactoylation

• Main Authors: Marissa N. Trujillo (Author), Erin Q. Jennings (Author), Emely A. Hoffman (Author), Hao Zhang (Author), Aiden M. Phoebe (Author), Grace E. Mastin (Author), Naoya Kitamura (Author), Julie A. Reisz (Author), Emily Megill (Author), Daniel Kantner (Author), Mariola M. Marcinkiewicz (Author), Shannon M. Twardy (Author), Felicidad Lebario (Author), Eli Chapman (Author), Rebecca L. McCullough (Author), Angelo D'Alessandro (Author), Nathaniel W. Snyder (Author), Darren A. Cusanovich (Author), James J. Galligan (Author)
• Format: Bog
• Udgivet: Elsevier, 2024-03-01T00:00:00Z.
• Fag: article
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Chronic, systemic inflammation is a pathophysiological manifestation of metabolic disorders. Inflammatory signaling leads to elevated glycolytic flux and a metabolic shift towards aerobic glycolysis and lactate generation. This rise in lactate corresponds with increased generation of lactoylLys modi...