LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer

• Main Authors: Goutam Dey (Author), Rashmi Bharti (Author), Chad Braley (Author), Ravi Alluri (Author), Emily Esakov (Author), Katie Crean-Tate (Author), Keith McCrae (Author), Amy Joehlin-Price (Author), Peter G. Rose (Author), Justin Lathia (Author), Zihua Gong (Author), Ofer Reizes (Author)
• Format: Book
• Published: BMC, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Poly-ADP Ribose Polymerase (PARP) targeted therapy is clinically approved for the treatment of homologous recombination (HR) repair deficient tumors. The remarkable success of this therapy in the treatment of HR repair deficient cancers has not translated to HR-proficient cancers. Our studi...