LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer

• Главные авторы: Goutam Dey (Автор), Rashmi Bharti (Автор), Chad Braley (Автор), Ravi Alluri (Автор), Emily Esakov (Автор), Katie Crean-Tate (Автор), Keith McCrae (Автор), Amy Joehlin-Price (Автор), Peter G. Rose (Автор), Justin Lathia (Автор), Zihua Gong (Автор), Ofer Reizes (Автор)
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• Опубликовано: BMC, 2023-06-01T00:00:00Z.
• Предметы: article
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Abstract Poly-ADP Ribose Polymerase (PARP) targeted therapy is clinically approved for the treatment of homologous recombination (HR) repair deficient tumors. The remarkable success of this therapy in the treatment of HR repair deficient cancers has not translated to HR-proficient cancers. Our studi...