Using Polymers as Crystal Inhibitors to Prevent the Crystallization of the Rotigotine Patch

• Main Authors: Qiantong Liu (Author), Xing Li (Author), Bo Liu (Author), Jiahao Kong (Author), Qing Wang (Author), Zhigang Gao (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to enhance the stability of the Rotigotine (ROT) patch using polymers as crystal inhibitors. Three polymers (Poloxamer 188, Soluplus, TPGS) were selected as crystal inhibitors to formulate ROT patches with varying drug loadings (20%, 40%, 60%, and 80%, <i>w</i>/<i>...