Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management

• Main Authors: Andreia Nunes (Author), Joana Marto (Author), Lídia Maria Gonçalves (Author), Sandra Simões (Author), Rita Félix (Author), Andreia Ascenso (Author), Francisca Lopes (Author), Helena Margarida Ribeiro (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human neutrophil elastase (HNE) is a serine protease that degrades matrix proteins. An excess of HNE may trigger several pathological conditions, such as psoriasis. In this work, we aimed to synthesize, characterize and formulate new HNE inhibitors with a 4-oxo-β-lactam scaffold with less toxicity,...