Association of 5-FU Therapeutic Drug Monitoring to DPD Phenotype Assessment May Reduce 5-FU Under-Exposure

• Main Authors: Marine Dolat (Author), Pauline Macaire (Author), Françoise Goirand (Author), Julie Vincent (Author), Audrey Hennequin (Author), Rémi Palmier (Author), Leïla Bengrine-Lefevre (Author), François Ghiringhelli (Author), Bernard Royer (Author), Antonin Schmitt (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In order to limit 5-fluorouracil (5-FU) toxicity, some health agencies recommend evaluating dihydropyrimidine dehydrogenase (DPD) deficiency before any 5-FU treatment introduction. In our study, we investigated relationships between 5-FU clearance and markers of DPD activity such as uracilemia (U),...