Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole

• Main Authors: Martin Juhás (Author), Andrea Bachtíková (Author), Daria Elżbieta Nawrot (Author), Paulína Hatoková (Author), Vinod Sukanth Kumar Pallabothula (Author), Adéla Diepoltová (Author), Ondřej Janďourek (Author), Pavel Bárta (Author), Klára Konečná (Author), Pavla Paterová (Author), Vít Šesták (Author), Jan Zitko (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antimicrobial drug resistance is currently one of the most critical health issues. Pathogens resistant to last-resort antibiotics are increasing, and very few effective antibacterial agents have been introduced in recent years. The promising drug candidates are often discontinued in the primary stag...