Structure Optimization of 12β-<em>O</em>-γ-Glutamyl Oleanolic Acid Derivatives Resulting in Potent FXR Antagonist/Modulator for NASH Therapy
The farnesoid X receptor (FXR) plays a crucial role in regulating the metabolism of bile acids, lipids, and sugars. Consequently, it is implicated in the treatment of various diseases, including cholestasis, diabetes, hyperlipidemia, and cancer. The advancement of novel FXR modulators holds immense...
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Main Authors: | , , , , , , , |
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Format: | Book |
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MDPI AG,
2023-05-01T00:00:00Z.
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A1234.567 |
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