Role of OATP1B1 and OATP1B3 in Drug-Drug Interactions Mediated by Tyrosine Kinase Inhibitors

• Główni autorzy: Dominique A. Garrison (Autor), Zahra Talebi (Autor), Eric D. Eisenmann (Autor), Alex Sparreboom (Autor), Sharyn D. Baker (Autor)
• Format: Książka
• Wydane: MDPI AG, 2020-09-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Failure to recognize important features of a drug's pharmacokinetic characteristics is a key cause of inappropriate dose and schedule selection, and can lead to reduced efficacy and increased rate of adverse drug reactions requiring medical intervention. As oral chemotherapeutic agents, tyrosin...