Effects of Pomegranate Seed and Peel Methanolic Extracts on Methotrexate-Induced Hepatotoxicity in Rats

• Main Authors: Farideh Doostan (Author), Mehran Mesgari Abbasi (Author), Monireh Khordadmehr (Author), Farnoush Fallah (Author), Azin Behrouzy (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Hepatotoxicity-the most important side effect of the Methotrexate (MTX)-seems to relate to the generation of reactive oxygen species. Pomegranate has high anti-oxidant capacities. We studied if MTX-induced hepatotoxicity can be protected by pomegranate peel and seed methanolic extracts (...