Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation

• Главные авторы: Hourinaz Behesti (Автор), Heeta Bhagat (Автор), Adrian M. Dubuc (Автор), Michael D. Taylor (Автор), Silvia Marino (Автор)
• Формат: ‌
• Опубликовано: The Company of Biologists, 2013-01-01T00:00:00Z.
• Предметы: article
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SUMMARY BMI1 is a potent inducer of neural stem cell self-renewal and neural progenitor cell proliferation during development and in adult tissue homeostasis. It is overexpressed in numerous human cancers - including medulloblastomas, in which its functional role is unclear. We generated transgenic...