Validation of a [3H]Astemizole Binding Assay in HEK293 Cells Expressing HERG K+ Channels

A radioligand binding assay for the HERG (human ether-a-go-go-related gene) K+ channel was developed to identify compounds which may have inhibitory activity and potential cardiotoxicity. Pharmacological characterization of the [3H]astemizole binding assay for HERG K+ channels was performed using HE...

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Main Authors: Peter J.S. Chiu (Author), Karen F. Marcoe (Author), Sidney E. Bounds (Author), Chun-Hsiung Lin (Author), Jin-Jye Feng (Author), Atsui Lin (Author), Fong-Chi Cheng (Author), William J. Crumb (Author), Richard Mitchell (Author)
Format: Book
Published: Elsevier, 2004-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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