Contact System Activation in Plasma from Dengue Patients Might Harness Endothelial Virus Replication through the Signaling of Bradykinin Receptors

• Main Authors: Sharton V. A. Coelho (Author), Naiara M. Rust (Author), Lucas Vellasco (Author), Michelle P. Papa (Author), Aline S. G. Pereira (Author), Matheus Ferreira da Silva Palazzo (Author), Maria Aparecida Juliano (Author), Simone M. Costa (Author), Ada M. B. Alves (Author), Marli T. Cordeiro (Author), Ernesto T. A. Marques (Author), Júlio Scharfstein (Author), Luciana B. de Arruda (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Since exacerbated inflammation and microvascular leakage are hallmarks of dengue virus (DENV) infection, here we interrogated whether systemic activation of the contact/kallikrein-kinin system (KKS) might hamper endothelial function. In vitro assays showed that dextran sulfate, a potent contact acti...