Iron Overload Impairs Bone Marrow Mesenchymal Stromal Cells from Higher-Risk MDS Patients by Regulating the ROS-Related Wnt/β-Catenin Pathway

• मुख्य लेखकों: Lei Huang (लेखक), Zhaoyun Liu (लेखक), Hui Liu (लेखक), Kai Ding (लेखक), Fu Mi (लेखक), Chenhuan Xiang (लेखक), Guanrou Wang (लेखक), Yixuan Guo (लेखक), Rong Fu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Hindawi Limited, 2020-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The bone marrow microenvironment plays important roles in the progression of the myelodysplastic syndrome (MDS). The higher incidence of ASXL1 and TET2 gene mutations in our iron overload (IO) MDS patients suggests that IO may be involved in the pathogenesis of MDS. The effects of IO damaging bone m...