The role of the immunoproteasome in cardiovascular disease

• Main Authors: Yifei Nie (Author), Zhao Ma (Author), Baoen Zhang (Author), Meichen Sun (Author), Dongfeng Zhang (Author), Hui-Hua Li (Author), Xiantao Song (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The ubiquitinproteasome system (UPS) is the main mechanism responsible for the intracellular degradation of misfolded or damaged proteins. Under inflammatory conditions, the immunoproteasome, an isoform of the proteasome, can be induced, enhancing the antigen-presenting function of the UPS. Further...