Dickkopf-1 (DKK1) blockade mitigates osteogenesis imperfecta (OI) related bone disease

• Main Authors: Jih-Yang Ko (Author), Feng-Sheng Wang (Author), Wei-Shiung Lian (Author), Fu-Shine Yang (Author), Jeng-Wei Chen (Author), Po-Hua Huang (Author), Chin-Yi Liao (Author), Shu-Jui Kuo (Author)
• Format: Book
• Published: BMC, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The current treatment of osteogenesis imperfecta (OI) is imperfect. Our study thus delves into the potential of using Dickkopf-1 antisense (DKK1-AS) to treat OI. Methods We analysed serum DKK1 levels and their correlation with lumbar spine and hip T-scores in OI patients. Compara...