Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model.

• Main Authors: Nada Abla (Author), Jennifer Keiser (Author), Mireille Vargas (Author), Natalie Reimers (Author), Helmut Haas (Author), Thomas Spangenberg (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

After more than 40 years of use, Praziquantel (PZQ) still remains the drug of choice for the treatment of intestinal and urogenital schistosomiasis. Its anti-parasitic activity resides primarily in the (R)-enantiomer. Hitherto neither the molecular target nor the pharmacokinetic-pharmacodynamic rela...